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Treatment strategies for adolescent and young adult patients with acute myeloid leukemia

Kristen O'Dwyer, David R. Freyer and John T. Horan

Abstract

Adolescents and young adults (AYA) form a unique group of patients with newly diagnosed acute myeloid leukemia. They differ in terms of disease biology, psychosocial challenges, survival and in other important respects from children as well as from middle age and older adults. AYA may be treated using pediatric protocols, developed in trials comprised primarily of younger patients, or using adult protocols, developed in trials comprised primarily of older patients. After reviewing the distinguishing characteristics of AYA with AML, we compare and contrasts the chemotherapy approaches and argue that neither the pediatric nor adult approaches may be ideally suited for AYA and the development of AYA specific approaches merits further consideration. We finish by putting forth ideas for future research to optimize chemotherapy treatment for AYA with AML.

  • Submitted December 18, 2017.
  • Accepted March 5, 2018.