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Extracellular galectins as controllers of cytokines in hematological cancer

Monica Gordon-Alonso, Annika M. Bruger and Pierre van der Bruggen

Abstract

Galectins and cytokines are both secreted proteins whose levels are prognosis factors for several cancers. Extracellular galectins bind to the glycans decorating glycoproteins and are overproduced in most cancers. Accumulative evidence shows that galectins regulate cytokines during cancer progression. While galectins alter cytokine function by binding to the glycans decorating cytokines or their receptors, cytokines could also regulate galectin expression and function. This review revises these complex interactions and their clinical impact, particularly in hematological cancers.

  • Submitted April 25, 2018.
  • Accepted May 31, 2018.