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The interplay of leukemia cells and the bone marrow microenvironment

Delfim Duarte, Edwin D. Hawkins and Cristina Lo Celso

Abstract

The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussions on the growth of leukemic cells are poorly understood. Recent development of novel imaging technology and preclinical disease models have advanced our comprehension of leukemia-microenvironment crosstalk and have potential implications for development of novel treatment options.

  • Submitted December 8, 2017.
  • Accepted February 9, 2018.