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Inflammation: a key regulator of hematopoietic stem cell fate in health and disease

Eric M. Pietras

Abstract

Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute needs such as infection or injury. Significant interest has emerged in how inflammation regulates HSC fate, and how it impacts the long-term functionality of HSCs and the blood system as a whole. Here we detail recent advances and unanswered questions at the intersection between inflammation and HSC biology in the contexts of development, aging and hematological malignancy.

  • Submitted June 19, 2017.
  • Accepted September 4, 2017.