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HLA-DP in unrelated hematopoietic cell transplantation revisited: challenges and opportunities

Katharina Fleischhauer and Bronwen E. Shaw

Abstract

When considering HLA-matched hematopoietic cell transplantation (HCT), sibling and unrelated donors (UD) are biologically different because UD-HCT is typically performed across HLA-DP disparities absent in sibling-HCT. Mismatched HLA-DP is the target of direct alloreactive T-cell responses with important implications for graft-versus-host-disease and graft-versus-leukemia. This concise review details the special features of HLA-DP as model antigens for clinically permissive mismatches mediating limited T-cell alloreactivity with minimal toxicity, and describes future avenues for their exploitation in cellular immunotherapy of malignant blood disorders.

  • Submitted March 23, 2017.
  • Accepted June 17, 2017.