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Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis

Kellie R. Machlus, Stephen K. Wu, Prakrith Vijey, Thomas S. Soussou, Zhi-Jian Liu, Eran Shacham, T.J. Unger, Trinayan Kashyap, Boris Klebanov, Martha Sola-Visner, Marsha Crochiere, Joseph E. Italiano Jr. and Yosef Landesman

Article Information

PubMed 

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Online ISSN 
History 
  • Submitted November 21, 2016
  • Accepted June 13, 2017
  • Published online June 19, 2017.

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Contributors 
  • Kellie R. Machlus, 1 Division of Hematology, Department of Medicine; Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States;
  • Stephen K. Wu, 1 Division of Hematology, Department of Medicine; Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States;
  • Prakrith Vijey, 1 Division of Hematology, Department of Medicine; Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States;
  • Thomas S. Soussou, 1 Division of Hematology, Department of Medicine; Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States;
  • Zhi-Jian Liu, 2 Department of Pediatrics, Harvard Medical School and Division of New Born Medicine, Boston Children's Hospital, Boston, MA, United States;
  • Eran Shacham, 3 Karyopharm Therapeutics, Newton, MA, United States
  • T.J. Unger, 3 Karyopharm Therapeutics, Newton, MA, United States
  • Trinayan Kashyap, 3 Karyopharm Therapeutics, Newton, MA, United States
  • Boris Klebanov, 3 Karyopharm Therapeutics, Newton, MA, United States
  • Martha Sola-Visner, 2 Department of Pediatrics, Harvard Medical School and Division of New Born Medicine, Boston Children's Hospital, Boston, MA, United States;
  • Marsha Crochiere, 3 Karyopharm Therapeutics, Newton, MA, United States
  • Joseph E. Italiano Jr., 1 Division of Hematology, Department of Medicine; Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States;
  • Yosef Landesman, 3 Karyopharm Therapeutics, Newton, MA, United States

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