The NCI Genomic Data Commons as an engine for precision medicine

Mark A. Jensen, Vincent Ferretti, Robert L. Grossman and Louis M. Staudt


The National Cancer Institute Genomic Data Commons (GDC) is an information system to store, analyze and share genomic and clinical data from patients with cancer. The recent high-throughput sequencing of cancer genomes and transcriptomes has produced a "big data" problem that precludes many cancer biologists and oncologists from gleaning knowledge from these data regarding the nature of the malignant process and the relationship between tumor genomic profiles and treatment response. The GDC aims to democratize access to cancer genomic data and to foster the sharing of these data to promote precision medicine approaches to the diagnosis and treatment of cancer.

  • Submitted March 6, 2017.
  • Accepted May 8, 2017.