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Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

Mohammed Dany, Salih Gencer, Rose Nganga, Raquela J. Thomas, Natalia Oleinik, Kyla D. Baron, Zdzislaw M. Szulc, Peter Ruvolo, Steven Kornblau, Michael Andreeff and Besim Ogretmen

Article Information

PubMed 

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History 
  • Submitted April 1, 2016
  • Accepted August 9, 2016
  • Published online August 18, 2016.

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Contributors 
  • Mohammed Dany, 1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States;
  • Salih Gencer, 2 Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States;
  • Rose Nganga, 1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States;
  • Raquela J. Thomas, 1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States;
  • Natalia Oleinik, 1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States;
  • Kyla D. Baron, 1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States;
  • Zdzislaw M. Szulc, 1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States;
  • Peter Ruvolo, 3 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
  • Steven Kornblau, 3 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
  • Michael Andreeff, 3 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
  • Besim Ogretmen, 1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States;

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