Blood Journal
Leading the way in experimental and clinical research in hematology

A perspective on the selection of unrelated donors and cord blood units for transplantation

  1. Stephen R. Spellman1,
  2. Mary Eapen2,
  3. Brent R. Logan3,
  4. Carlheinz Mueller4,
  5. Pablo Rubinstein5,
  6. Michelle I. Setterholm6,
  7. Ann E. Woolfrey7,
  8. Mary M. Horowitz2,*,
  9. Dennis L. Confer6, and
  10. Carolyn K. Hurley8
  1. 1 Center for International Blood and Marrow Transplant Research, Minneapolis, MN, United States;
  2. 2 Center for Blood and Marrow Transplant Research, Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States;
  3. 3 Center for International Blood and Marrow Transplant Research, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States;
  4. 4 German National Bone Marrow Registry, Ulm, Germany;
  5. 5 National Cord Blood Program, New York Blood Center, New York, NY, United States;
  6. 6 National Marrow Donor Program, Minneapolis, MN, United States;
  7. 7 Fred Hutchinson Cancer Research Center, Seattle, WA, United States;
  8. 8 Department of Oncology, Georgetown University, Washington, DC, United States
  1. * Corresponding author; email: marymh{at}mcw.edu

Abstract

Selection of a suitable graft for allogeneic hematopoietic stem cell transplantation involves consideration of both donor and recipient characteristics. Of primary importance is sufficient donor-recipient human leukocyte antigen (HLA) matching to ensure engraftment and acceptable rates of graft-versus-host disease. In this perspective, the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research (CIBMTR) provide guidelines, based on large studies correlating graft characteristics with clinical transplantation outcomes, on appropriate typing strategies and matching criteria for unrelated adult donor and cord blood graft selection.

  • Submitted March 6, 2012.
  • Accepted May 4, 2012.