Blood Journal
Leading the way in experimental and clinical research in hematology

Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy

  1. NJ Chao,
  2. JR Schriber,
  3. K Grimes,
  4. GD Long,
  5. RS Negrin,
  6. CM Raimondi,
  7. SJ Horning,
  8. SL Brown,
  9. L Miller, and
  10. KG Blume
  1. Department of Medicine, Stanford University Medical Center, CA 94305.

Abstract

Hematopoietic growth factors have been used to accelerate engraftment after bone marrow transplantation and to “mobilize” peripheral blood progenitor cells (PBPC). We report on the data in 85 consecutive patients with Hodgkin's disease who were treated in a single institution using different methods to obtain PB progenitor cells. Use of granulocyte colony-stimulating factor for mobilization resulted in a significantly accelerated time to recovery of granulocytes (10 days v 12 days, P < .01) when compared with “nonmobilized” PBPC recipients. Similarly, use of mobilized PBPC resulted in a significantly accelerated time to platelet engraftment (13 days v 30 days, P < .001) when compared with “nonmobilized” recipients. Moreover, there was a statistically significant difference in total costs in favor of the group receiving “mobilized” PBPC.