Blood Journal
Leading the way in experimental and clinical research in hematology

Therapy of chronic idiopathic thrombocytopenic purpura in adults [see comments]

  1. P Berchtold and
  2. R McMillan
  1. Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, CA 92037.


Chronic ITP is a common hematologic illness. Approximately three fourths of the patients respond to corticosteroids or splenectomy and need no further treatment. Patients refractory to these two therapeutic approaches are relatively resistant to present forms of treatment and are at much greater risk for morbidity and mortality. Future clinical studies evaluating therapy in this refractory group would be best performed in a cooperative group setting in which large numbers of patients could be treated in a prospective randomized manner.