Blood Journal
Leading the way in experimental and clinical research in hematology

Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature

  1. E Benz-Lemoine,
  2. A Brizard,
  3. JL Huret,
  4. P Babin,
  5. F Guilhot,
  6. D Couet, and
  7. J Tanzer
  1. Department of Hematology, Hopital Jean Bernard, Poitiers, France.


In this paper, the investigators report a well documented case of malignant histiocytosis (MH) with a t(2;5)(p23;q35) translocation. A breakpoint in 5q35 appears to be specific, either for the disease or for a subclass of the disease. Additional cases of MH with cytogenetics are needed. This will help to determine if one class of MH or several subclasses can be defined by cytogenetic anomaly(ies).