Blood Journal
Leading the way in experimental and clinical research in hematology

Bone marrow ablation followed by allogeneic marrow grafting during first complete remission of acute nonlymphocytic leukemia

  1. SJ Forman,
  2. WE Spruce,
  3. MJ Farbstein,
  4. JL Wolf,
  5. EP Scott,
  6. AP Nademanee,
  7. JL Fahey,
  8. T Hecht,
  9. JA Zaia,
  10. RA Krance,
  11. DO Findley, and
  12. KG Blume

Abstract

Of 33 patients who had undergone allogeneic bone marrow transplantation during first complete remission of acute nonlymphocytic leukemia, 21 patients have now been followed in continued complete remission for 6- 64 mo (median greater than 18 mo) without maintenance chemotherapy. The median age of the surviving patients is 27 yr. Transplant-related complications occurring throughout the first year after marrow grafting were fatal in 7 patients, and leukemic recurrence led to the death of 5 patients. The actuarial long-term disease-free survival is 60% and the actuarial remission rate is 79%.