Blood Journal
Leading the way in experimental and clinical research in hematology

Recessive Familial Erythrocytosis: Aspects of Marrow Regulation in Two Families

  1. John W. Adamson, M.D., Assistant Professor of Medicine,
  2. George Stamatoyannopoulos, M.D., Associate Professor of Medicine,
  3. Stella Kontras, M.D., Professor of Pediatrics,
  4. Andre Lascari, M.D., Professor of Pediatrics, and
  5. James Detter, M.D., Assistant Professor of Laboratory Medicine
  1. Divisions of Hematology and Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, Wash. 98105, the Department of Pediatrics, Ohio State University School of Medicine, Columbus, Ohio 43210; and the University of Iowa School of Medicine, Iowa City, Iowa 52240.
  2. University of Washington, Seattle, Wash. 98105; recipient of a Clinical Investigatorship of the Veterans' Administration.
  3. University of Washington, Seattle, Wash. 98105.
  4. Ohio State University, Columbus, Ohio 43210.
  5. Southern Illinois University, Springfield, Ill.; formerly Associate Professor of Pediatrics, University of Iowa, Iowa City, Iowa 52240.
  6. University of Washington, Seattle, Wash. 93105.

Abstract

Studies of marrow regulation were carried out in two families with recessively expressed erythrocytosis. The erythrocytosis in the affected individuals was associated with increased erythropoietin (ESF) production. However, hormone production was uninfluenced by alterations in the O2 carrying capacity of the blood when the hematocrit was lowered acutely by phlebotomy. Hemoglobin and red cell function (p50; 2, 3-diphosphoglycerate) in the affected, as well as the unaffected, family members were normal. Renal arteriography revealed no mass lesions and no anatomic abnormalities of the renal macro- or microvasculature. Antisera capable of neutralizing the biological activity of normal human ESF completely inhibited the erythropoietic activity in the serum and urine of those studied. Since increased production of ESF occurred in the absence of recognizable physiologic requirements and since the normal reciprocal relationship between O2 delivery and hormone production was absent, the most likely explanation for this clinical constellation is a cellular defect in the regulation of production of ESF or of its precursor substances.

  • Submitted May 11, 1972.
  • Revision received October 11, 1972.
  • Accepted October 13, 1972.