Blood Journal
Leading the way in experimental and clinical research in hematology

Paroxysmal Nocturnal Hemoglobinuria: Evidence for Monoclonal Origin of Abnormal Red Cells

  1. S. B. ONI, M.B., B.S., M.C.R.S., D.T.M. & H., D.T.C.D., Specialist Physician,
  2. B. O. OSUNKOYA, MB., B.S., PH.D.,, Senior Lecturer in Pathology, and
  3. L. LUZZATTO, M.D., Professor of Hematology
  1. Subdepartment of Hematology, Department of Pathology, University College Hospital, Ibadan, Nigeria.
  2. Adeoyo State Hospital and Government Chest Clinic, Ibadan, Nigeria.
  3. University College Hospital, Ibadan, Nigeria.
  4. University College Hospital, Ibadan, Nigeria.

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) was diagnosed in a 26-year-old Nigerian woman who subsequently died of amebic colitis. The patient’s red cells exhibited mosaicism with respect to glucose 6-phosphate dehydrogenase, in that some of them had the A, and some of them had the B variant of this enzyme (as expected in female subjects heterozygous at this sex-linked locus). The red cells bearing the PNH abnormality only had the B variant, suggesting that they all belonged to a single abnormal clone.

  • Submitted October 27, 1969.
  • Accepted January 12, 1970.