Blood Journal
Leading the way in experimental and clinical research in hematology

Polycythemia Vera with Ph1 Chromosomes in Two Brothers

  1. WILLIAM C. LEVIN, M.D., Professor of Medicine,
  2. ELSIE W. HOUSTON, M.Sc., Research Associate, and
  3. STEPHAN E. RITZMANN, M.D., Research Associate Professor
  1. Department of Medicine, Hematology Research Laboratory and the Shriners Burns Institute, Division of Hematology, University of Texas Medical Branch, Galveston, Texas.
  2. Divison of Hematology, University of Texas Medical Branch.
  3. Divison of Hematology, University of Texas Medical Branch.
  4. Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch.

Abstract

Two brothers with polycythemia rubra vera have been studied: one before treatment and one after many years of treatment. Direct harvests of marrow aspirates from both patients exhibited the presence of the Ph1 chromosome. Moderately increased LAP levels were present in both. Available data do not indicate whether the disease and the chromosomal aberrations in these two brothers are familial or fortuitous.

  • Submitted October 19, 1966.
  • Accepted April 24, 1967.