Blood Journal
Leading the way in experimental and clinical research in hematology

Jordans’ Anomaly in White Blood Cells

  1. L. ROZENSZAJN, PH.D., Head of the Laboratories,
  2. A. KLAJMAN, M.D., Chief,
  3. D. YAFFE, PH.D., Section of Cell Biology, and
  4. P. EFRATI, M.D., Associate Professor of Medicine
  1. Meir Hospital, Kfar-Saba, Israel.
  2. Meir Hospital of the Laborer's Sick Fund, Kfar-Saba, Israel; Lecturer in Hematology, Department of Microbiology, Bar-Ilaim Unicersity, Ranmat-Gan, Israel.
  3. Medical Department B, Meir Hospital of time Laborer's Sick Fund, Kfar-Saba, Israel.
  4. The Weizinann Institute of Science, Rehovoth, Israel.
  5. The Hebrew University-Hadassah Medical School, Jerusalem, Israel; Director, Laboratory for Blood Morphology and Cytology, Kaplan Hospital of the Laborer's Sick Fund, Rehovoth, Israel.

Abstract

Persistent vacuoles were seen in the protoplasm of granulocytes, monocytes and occasional lymphocytes of 2 sisters suffering from ichthyosis. In the bone marrow these vacuoles were found in the cytoplasm of promyelocytes, myelocytes, metamyelocytes and rarely in plasma cells. They were not observed in blasts or in red cells and thrombocytes and their precursors.

With the help of cytochemical staining technics and fluorescence microscopy studies, it was determined that the vacuoles contained lipids. A similar abnormality of leukocytes was described previously by Jordans in 2 brothers suffering from muscular dystrophy.

Ichthyosis was transmitted in this family in an autosomal recessive way.

  • Submitted September 14, 1965.
  • Accepted December 10, 1965.