Blood Journal
Leading the way in experimental and clinical research in hematology

The Regenerative Ability of Hemopoietic Tissue Following Lethal X-Irradiation in Dogs

  1. VICTOR PERMAN, D.V.M., Instructor,
  2. EUGENE P. CRONKITE, M.D., Head,
  3. VICTOR P. BOND, M.D.,Ph.D., Assistant Department Chairman, and
  4. DALE K. SORENSEN, D.V.M.,Ph.D., Associate Professor
  1. Medical Research Center, Brookhaven National Laboratory, Upton, L.I., N. Y.
  2. School of Veterinary Medicine, University of Minnesota, St. Paul, Minn. Research Collaborator, Medical Research Center, Brookhaven National Laboratory, Upton, N. Y.
  3. Medical Research Center, Brookhaven National Laboratory, Upton, N. Y.
  4. Medical Research Center, and Head, Division of Microbiology, Brookhaven National Laboratory, Upton, N. Y.
  5. Division of Veterinary Medicine and Clinics, University of Minnesota, St. Paul, Minn. Research Collaborator, Medical Research Center, Brookhaven National Laboratory, Upton, N. Y.

Abstract

1. Successful treatment of the hemopoietic phase of the acute irradiation syndrome in dogs at the LD100 (400 r) dose is possible on an individual case basis with good nursing care.

2. The onset and rate of regeneration is related to the radiation dose. Partial regeneration with subsequent death occurs with a 550 r dose.

3. The control of infection during the critical period prior to regeneration appeared to be the limiting factor in successful treatment at the dose levels used in this study.