Blood Journal
Leading the way in experimental and clinical research in hematology

The Pelger-Huët Anomaly in Three Families and Its Use in Determining the Disappearance of Transfused Neutrophils from the Peripheral Blood

  1. WENDELL F. ROSSE and
  2. CLIFFORD W. GURNEY
  1. Argonne Cancer Research Hospital, USAEC, and the Department of Medicine, The University of Chicago, Illinois.

Abstract

1. Thirteen cases of Pelger-Huët anomaly occurring in three families are presented and discussed. The second recorded case of the anomaly in Negroes is included; the occurrence of familial hereditary elliptocytosis in this same family and the possible relationship to the Pelger-Huët anomaly are discussed.

2. Certain less well-known facts about Pelger-Huët anomaly are considered in relation to the cases presented.

3. The survival time of transfused neutrophils in the peripheral blood was investigated using the anomaly as a tagging device. Most of the cells were found to be absent from the peripheral blood stream in 6 to 8 hours, and none was found after 49.5 hours.