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TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Pavel Davizon-Castillo, Brandon McMahon, Sonia Aguila, David Bark, Katrina Ashworth, Ayed Allawzi, Robert A. Campbell, Emilie Montenont, Travis Nemkov, Angelo D’Alessandro, Nathan Clendenen, Lauren Shih, Natalie A. Sanders, Kelly Higa, Allaura Cox, Zavelia Padilla-Romo, Giovanni Hernandez, Eric Wartchow, George D. Trahan, Eva Nozik-Grayck, Kenneth Jones, Eric M. Pietras, James DeGregori, Matthew T. Rondina and Jorge Di Paola

Article Information

Citation 
vol. 134 no. 9 727-740
PubMed 

Print ISSN 
Online ISSN 
History 
  • Submitted February 16, 2019
  • Accepted July 2, 2019
  • Published online August 29, 2019.

Article Versions


Contributors 
  • Pavel Davizon-Castillo, 1Center for Cancer and Blood Disorders, Department of Pediatrics and
  • Brandon McMahon, 2Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO;
  • Sonia Aguila, 3Irish Center for Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland;
  • David Bark, 4Department of Mechanical Engineering, Colorado State University, Fort Collins, CO;
  • Katrina Ashworth, 1Center for Cancer and Blood Disorders, Department of Pediatrics and
  • Ayed Allawzi, 5Cardiovascular Pulmonary Research Laboratory, Department of Pediatrics and 6Cardiovascular Pulmonary Research Laboratory, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO;
  • Robert A. Campbell, 7Molecular Medicine Program and 8Department of Internal Medicine, University of Utah, Salt Lake City, UT;
  • Emilie Montenont, 7Molecular Medicine Program and 8Department of Internal Medicine, University of Utah, Salt Lake City, UT;
  • Travis Nemkov, 9Department of Biochemistry and Molecular Genetics and
  • Angelo D’Alessandro, 9Department of Biochemistry and Molecular Genetics and
  • Nathan Clendenen, 10Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO;
  • Lauren Shih, 11Department of Internal Medicine, University of Washington, Seattle, WA;
  • Natalie A. Sanders, 12Division of Geriatrics, University of Utah, Salt Lake City, UT; 13Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center (VAMC), Salt Lake City, UT;
  • Kelly Higa, 9Department of Biochemistry and Molecular Genetics and
  • Allaura Cox, 1Center for Cancer and Blood Disorders, Department of Pediatrics and
  • Zavelia Padilla-Romo, 14División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México;
  • Giovanni Hernandez, 2Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO;
  • Eric Wartchow, 15Department of Pathology and Laboratory Medicine, Children’s Hospital Colorado, Aurora, CO; and
  • George D. Trahan, 1Center for Cancer and Blood Disorders, Department of Pediatrics and
  • Eva Nozik-Grayck, 5Cardiovascular Pulmonary Research Laboratory, Department of Pediatrics and 6Cardiovascular Pulmonary Research Laboratory, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO;
  • Kenneth Jones, 1Center for Cancer and Blood Disorders, Department of Pediatrics and
  • Eric M. Pietras, 2Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO;
  • James DeGregori, 9Department of Biochemistry and Molecular Genetics and
  • Matthew T. Rondina, 7Molecular Medicine Program and 8Department of Internal Medicine, University of Utah, Salt Lake City, UT; 13Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center (VAMC), Salt Lake City, UT; 16Department of Pathology, University of Utah, Salt Lake City, UT
  • Jorge Di Paola, 1Center for Cancer and Blood Disorders, Department of Pediatrics and

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