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Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis

Kellie R. Machlus, Stephen K. Wu, Prakrith Vijey, Thomas S. Soussou, Zhi-Jian Liu, Eran Shacham, T. J. Unger, Trinayan Kashyap, Boris Klebanov, Martha Sola-Visner, Marsha Crochiere, Joseph E. Italiano Jr and Yosef Landesman

Article Information

Citation 
vol. 130 no. 9 1132-1143
PubMed 

Print ISSN 
Online ISSN 
History 
  • Submitted November 20, 2016
  • Accepted June 13, 2017
  • Published online August 31, 2017.

Article Versions


Contributors 
  • Kellie R. Machlus, 1Division of Hematology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA;
  • Stephen K. Wu, 1Division of Hematology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA;
  • Prakrith Vijey, 1Division of Hematology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA;
  • Thomas S. Soussou, 1Division of Hematology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA;
  • Zhi-Jian Liu, 2Department of Pediatrics, Harvard Medical School, Boston, MA; 3Division of New Born Medicine, Boston Children's Hospital, Boston, MA;
  • Eran Shacham, 4Karyopharm Therapeutics, Newton, MA; and
  • T. J. Unger, 4Karyopharm Therapeutics, Newton, MA; and
  • Trinayan Kashyap, 4Karyopharm Therapeutics, Newton, MA; and
  • Boris Klebanov, 4Karyopharm Therapeutics, Newton, MA; and
  • Martha Sola-Visner, 2Department of Pediatrics, Harvard Medical School, Boston, MA; 3Division of New Born Medicine, Boston Children's Hospital, Boston, MA;
  • Marsha Crochiere, 4Karyopharm Therapeutics, Newton, MA; and
  • Joseph E. Italiano Jr, 1Division of Hematology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; 5Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Boston, MA
  • Yosef Landesman, 4Karyopharm Therapeutics, Newton, MA; and

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