Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma

Richard J. Lin, Madhusmita Behera, Catherine S. Diefenbach and Christopher R. Flowers
This article has an Erratum 131(9):1037


Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making.

  • Submitted May 30, 2017.
  • Accepted August 14, 2017.
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