Red blood cells in thrombosis

James R. Byrnes and Alisa S. Wolberg

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  • RE: Red blood cell a culprit for thrombosis
    • Jean-Luc T. WAUTIER, Emeritus professor in medicine Universite Denis Diderot Paris7, Paris France
    • Other Contributors:
      • Marie-Paule S. WAUTIER, Honorary engineer

    Jean-Luc Wautier, Emeritus Professor in Medicine, Universite Denis Diderot Paris7, Paris France Other contributor: Marie-Paule Wautier Honorary Engineer, Institut National de la Santé et de la Recherche Medicale

    The review article entitled Red Blood Cells in thrombosis by JR Barnes and AS Wolberg (1) is an excellent start to reactive the concept of red blood cell (RBC) as a culprit for thrombosis. The authors quoted numerous articles dealing with different concepts in which RBC may be involved in thrombosis via platelet activation, rheological mechanisms and interaction with endothelium. Since the publication of erythrocyte adhesion in 1981 (2), several publications described the consequences of RBC interaction with endothelium mostly in sickle cell anemia. In diabetes mellitus one major mechanism is the activation of a cascade reaction leading to NADPH oxidase stimulation, NFkB activation and consequently gene expression of factors implied in inflammatory reaction (3). Alternatively as mentioned by the authors the molecular mechanism has been largely investigated and contributes to the understanding of thrombotic but also atherothrombotic consequences in several diseases: diabetes mellitus, polycythemia vera (4), sickle cell disease, ocular vascular thrombotic complications. Recently the risk factors for retinal vascular diseases were listed including hemodynamic particularities, anti-phospholipid synd...

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    Conflict of Interest:
    None declared.