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September 07, 2017; 130 (10)

Cover image expansion

Three-dimensional structure of the human NUDT15 protein. Green and cyan indicate chain A and B in the NUDT15 homodimer. Red and blue colors highlight amino acid residues affected by genetic polymorphisms that are related to thiopurine drug toxicity in patients. The NUDT15 substrate thioguanine monophosphate is shown in a stick-ball representation. See the article by Moriyama et al on page 1209.