Ups and downs of the ADP phosphoproteome

Zoltan Nagy and Yotis A. Senis

Article Figures & Data


  • The study by Beck et al reveals a dynamic pool of phosphorylation events downstream of the ADP receptors P2Y1 and P2Y12 that are counteracted by the prostaglandin I2 (PGI2) analog iloprost, which signals via protein kinase A (PKA). Phosphatases are shown to play a central role in regulating these phosphorylation events; however, biochemical links to the receptors remain ambiguous. AC, adenylate cyclase; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; PGI2R, prostaglandin I2 receptor. Professional illustration by Patrick Lane, ScEYEnce Studios.