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March 23, 2017; 129 (12)

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Incorporation of polyphosphate nanoparticles into platelet aggregates. The image shows a cross-section of platelet aggregates (bright-field microscopy; 2.9 μm from the surface), formed by flowing citrated whole blood over immobilized collagen at a shear rate of 1600 s−1 for 10 minutes. Extracellular platelet polyphosphate was simultaneously visualized by fluorescence microscopy with SYTOX (orange). See the article by Verhoef et al on page 1707.