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Hospital volume and acute myeloid leukemia mortality in Medicare beneficiaries aged 65 years and older

Michael P. Thompson, Teresa M. Waters, Erin K. Kaplan, Caitlin N. McKillop and Mike G. Martin

Article Figures & Data

Figures

  • Figure 1

    Adjusted ORs. Adjusted ORs comparing (A) 30-day and (B) 1-year mortality in very-high- and high-volume hospitals to low-volume hospitals for the overall sample and stratified by selected clinical factors (*P < .05, †P < .01, ‡P < .001). CCI, Charlson Comorbidity Index.

Tables

  • Table 1

    Characteristics and mortality rates for AML patients aged 65 years and older by hospital volume category (n = 7568)

    VariableTotalHospital volume categoryP*
    Low (<8 cases)High (8-15 cases)Very high (16-129 cases)
    No. of hospitals, %1895 (100)1706 (90.0)138 (7.3)51 (2.7)
    Median annual cases (IQR)2 (1-5)2 (1-4)10 (9-12)25 (19-34)
    No. of patients, %7568 (100)4450 (60.0)1499 (19.8)1529 (20.2)
    Patient characteristics, %
     Male56.755.957.058.7.16
     Race.04
      White88.888.690.687.7
      Black6.66.56.27.4
      Other4.64.93.15.0
     Age category, y<.001
      65-6921.516.525.431.5
      70-7942.740.343.647.3
      80+36.643.131.021.3
     Index admission type<.001
      Emergent58.765.552.844.2
      Nonemergent41.334.547.255.8
     Received chemotherapy at index admission26.114.536.450.3<.001
     Mean Charlson Comorbidity Index (SD)3.3 (1.5)3.4 (1.5)3.2 (1.4)3.0 (1.4)<.001
      ≤235.534.741.849.3<.001
      3-443.545.542.638.1
      5+17.519.815.612.6
    30-day mortality
     Unadjusted36.042.133.819.8<.001
     Risk-adjusted31.432.032.128.1<.001
    1-year mortality
     Unadjusted72.778.269.459.6<.001
     Risk-adjusted71.071.471.269.3<.001
    • IQR, interquartile range; SD, standard deviation.

    • * P values based on χ2 tests and Student t tests for categorical and continuous variables, respectively.