A booster shot to cure hemoglobinopathies

Mark C. Walters and Tippi C. MacKenzie

Article Figures & Data


  • This schematic illustrates the induction of tolerance after in utero transplantation, which is followed by a second “booster” transplant after birth with the same donor to establish donor-host mixed chimerism. The level of chimerism after the “booster” is sufficient for a clinical effect. MHC, major histocompatibility complex.