Blood Journal
Leading the way in experimental and clinical research in hematology

Review Series: Advances in Hematopoietic Cell Transplantation
Conditioning regimens for hematopoietic cell transplantation: one size does not fit all

  1. Boglarka Gyurkocza1,2 and
  2. Brenda M. Sandmaier3,4
  1. 1Memorial Sloan Kettering Cancer Center, New York, NY;
  2. 2Weill Cornell Medical College of Cornell University, New York, NY;
  3. 3Fred Hutchinson Cancer Research Center, Seattle, WA; and
  4. 4University of Washington School of Medicine, Seattle, WA

ORCID Profiles

Abstract

An essential component of allogeneic and autologous hematopoietic cell transplantation (HCT) is the conditioning regimen administered before the hematopoietic cell infusion. Early regimens relied on dose intensity, assuming that high-dose chemoradiotherapy would eliminate malignant disease and reinfusion of the graft would then restore hematopoiesis. However, as the contribution of graft-versus-tumor effects to the success of allogeneic HCT was recognized over time, in an effort to exploit these, many investigators lowered the dose of radiation and chemotherapeutic agents in the preparative regimen. This resulted in a major paradigm shift, and consequently, the pool of eligible patients underwent a remarkable expansion. In this article, we provide a review of the definition of high-dose, reduced-intensity, and nonmyeloablative conditioning regimens, the most commonly used agents and combinations, and the evolution of some early regimens. We also provide a brief review of the toxicities associated with these regimens.

  • Submitted February 14, 2014.
  • Accepted May 8, 2014.
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