Blood Journal
Leading the way in experimental and clinical research in hematology

Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial

  1. Pier Mannuccio Mannucci1,
  2. Christine Kempton2,
  3. Carolyn Millar3,
  4. Edward Romond4,
  5. Amy Shapiro5,
  6. Ingvild Birschmann6,
  7. Margaret V. Ragni7,
  8. Joan Cox Gill8,
  9. Thynn Thynn Yee9,
  10. Robert Klamroth10,
  11. Wing-Yen Wong11,
  12. Miranda Chapman11,
  13. Werner Engl11,
  14. Peter L. Turecek11,
  15. Tobias M. Suiter11, and
  16. Bruce M. Ewenstein11,
  17. and members of the rVWF Ad Hoc Study Group
  1. 1Hemophilia and Thrombosis Center and Scientific Direction, IRCCS Ca’ Granda Maggiore Policlinico Hospital Foundation and University of Milan, Milan, Italy;
  2. 2Departments of Pediatrics and of Hematology and Medical Oncology, Emory University, Atlanta, GA;
  3. 3Centre for Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom;
  4. 4Hemophilia Treatment Center, University of Kentucky, Lexington, KY;
  5. 5Indiana Hemophilia and Thrombosis Center, Indianapolis, IN;
  6. 6Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center, Ruhr University of Bochum, Bad Oeynhausen, Germany;
  7. 7Division Hematology/Oncology, Department of Medicine, University of Pittsburgh, and Hemophilia Center of Western Pennsylvania, Pittsburgh, PA;
  8. 8Medical College of Wisconsin and Blood Center of Wisconsin, Milwaukee, WI;
  9. 9Katharine Dormandy Haemophilia Centre, Royal Free Hospital London, London, United Kingdom;
  10. 10Vivantes Klinikum im Friedrichshain, Hemophilia Treatment Center, Berlin, Germany; and
  11. 11Baxter BioScience, Vienna, Austria and Westlake Village, CA

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