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Comparison Of Umbilical Cord Blood and Haploidentical Donor Grafts In Adults With High Risk Hematologic Diseases After Fludarabine Cyclophosphamide and TBI 2 Gy Based Reduced-Intensity Conditioning Regimen Stem Cell Transplantation

El-Cheikh Jean, Crocchiolo Roberto, Fürst Sabine, Bramanti Stefania, Sarina Barbara, Granata Angela, Faucher Catherine, Mohty Bilal, Harbi Samia, Bouabdallah Reda, Vey Norbert, Santoro Armando, Chabannon Christian, Castagna Luca and Didier Blaise

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Tables

  • Table 1

    Patient and transplantation characteristics:

    Characteristic Total =150 patientsHaplo transplant (n = 69)CB transplant (n = 81)P value
    Patients Age years (median) [range]44 (19-68)47 (18-66)
    Patients sexns
    Male39 (57)46 (57)
    Female30 (43)35 (43)
    Disease type
    AML3 (4)37 (46)<0.0001
    ALL1 (1)14 (17)<0.0001
    NHL24 (35)14 (17)ns
    HL30 (43)2 (2)<0.0001
    MM4 (6)2 (2)ns
    CLL5 (7)4 (5)ns
    CML01 (1)ns
    MDS/ MPS2 (3)7 (9)ns
    Status of disease
    CR37 (54)56 (69)ns
    PR/SD24 (35)12 (15)0.04
    PD8 (11)13 (16)ns
    Donor type
    Sibiling32 (46)
    Parent18 (26)
    Child18 (26)
    cousin1 (2)
    Donor/recipient sex mis-match34 (49)56 (69)ns
    ABO incompatibility24560.02
    Conditioning regimen
    Flu 5+Cy 1+ TBI075 (93)
    Flu 5+Cy 2+ TBI69 (100)6 (7)
    Stem cell source
    Peripheral Blood19 (28)
    Bone Marrow50 (72)
    Stem cell dose median [range] CD34+ x 106/kg3,96 (0,8-14)0,9 (0,08-1,28)
    GvHD prophylaxis
    CSA+MMF69 (100)81 (100)ns
    Cy post transplant69 (100)0
    Days with ANC< 500 x 109/l20 (14-39)22 (6-67)ns
    Days with platelets<20 x 109/l29 (14-50)41 (18-80)ns