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Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration

Austen J. J. Worth, Joao Metelo, Gerben Bouma, Dale Moulding, Marco Fritzsche, Bertrand Vernay, Guillaume Charras, Giles O. C. Cory, Adrian J. Thrasher and Siobhan O. Burns

Article Information

Citation 
vol. 121 no. 1 72-84
PubMed 

Print ISSN 
Online ISSN 
History 
  • Submitted January 13, 2012
  • Accepted October 11, 2012
  • Published online January 3, 2013.

Article Versions


Contributors 
  • Austen J. J. Worth, 1Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom; 2Great Ormond Street Hospital National Health Service Trust, London, United Kingdom;
  • Joao Metelo, 1Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom;
  • Gerben Bouma, 1Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom;
  • Dale Moulding, 1Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom;
  • Marco Fritzsche, 3London Centre for Nanotechnology and Department of Physics and Astronomy, University College London, London, United Kingdom;
  • Bertrand Vernay, 4Neural Development Unit, Institute of Child Health, University College London, London, United Kingdom;
  • Guillaume Charras, 5London Centre for Nanotechnology and Department of Cell & Developmental Biology, University College London, London, United Kingdom; and
  • Giles O. C. Cory, 6Peninsula College of Medicine and Dentistry, Peninsula Medical School, University of Exeter, St Luke's Campus, Exeter, United Kingdom
  • Adrian J. Thrasher, 1Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom; 2Great Ormond Street Hospital National Health Service Trust, London, United Kingdom;
  • Siobhan O. Burns, 1Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom; 2Great Ormond Street Hospital National Health Service Trust, London, United Kingdom;

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