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How we choose factor VIII to treat hemophilia

Pier Mannuccio Mannucci, Maria Elisa Mancuso and Elena Santagostino

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  • Risk of variant Creutzfeldt-Jakob disease and ethical considerations in factor VIII choice to treat hemophilia
    • Achille AOUBA, MD
    • Other Contributors:
      • Achille AOUBA, Annie Harroche, Marie-Francoise Torchet, Marie-France Mamzer-Brunel, Chantal Rothschild

    To the Editor. We read with great interest the article by Mannucci et al, who, like the Word Federation of Hemophilia, do not express a preference for recombinant products (RP) over plasma-derived products (PdP) in previously untreated patients (PUPs) with hemophilia 1, 2. This choice is based essentially on a possible lower risk of developing inhibitors and on the currently "impeccable" safety record and lower cost of P...

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    Conflict of Interest:
    None declared.
  • Treatment of Hemophilia A in countries with limited resources
    • Daniel P. Hart, Senior Lecturer Haematology
    • Other Contributors:
      • Paul Batty and Sean Platton

    As new participants in the World Federation of Hemophilia Twinning program, we have gained a valuable insight into the influence of published medical literature on the global readership. The inherent bias of published manuscripts towards practice in the developed world, pose significant professional and ethical dilemmas for the clinician developing a service in a country with limited resources. Such dilemmas are addressed...

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    Conflict of Interest:
    None declared.