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May 03, 2012; 119 (18)

Cover image expansion

Position of the prevalent atypical hemolytic uremic syndrome mutation, affecting complement C3 R139 residue (in black) on the structures of C3b with Factor B (FB) in closed (refractory to cleavage by Factor D) and open (prone to cleavage by Factor D) conformations. The α and β chains of C3b are depicted in blue and green and FB is colored in magenta. See the article by Roumenina et al on page 4182.