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Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

Sarah E. M. Herman, Amber L. Gordon, Amy J. Wagner, Nyla A. Heerema, Weiqiang Zhao, Joseph M. Flynn, Jeffrey Jones, Leslie Andritsos, Kamal D. Puri, Brian J. Lannutti, Neill A. Giese, Xiaoli Zhang, Lai Wei, John C. Byrd and Amy J. Johnson

Article Information

Citation 
vol. 116 no. 12 2078-2088
PubMed 

Print ISSN 
Online ISSN 
History 
  • Submitted February 25, 2010
  • Accepted May 24, 2010
  • Published online September 23, 2010.

Article Versions


Contributors 
  • Sarah E. M. Herman, 1Integrated Biomedical Science Graduate Program, 2Division of Hematology and Oncology, Department of Internal Medicine, and
  • Amber L. Gordon, 2Division of Hematology and Oncology, Department of Internal Medicine, and
  • Amy J. Wagner, 2Division of Hematology and Oncology, Department of Internal Medicine, and
  • Nyla A. Heerema, 3Department of Pathology, The Ohio State University, Columbus;
  • Weiqiang Zhao, 3Department of Pathology, The Ohio State University, Columbus;
  • Joseph M. Flynn, 2Division of Hematology and Oncology, Department of Internal Medicine, and
  • Jeffrey Jones, 2Division of Hematology and Oncology, Department of Internal Medicine, and
  • Leslie Andritsos, 2Division of Hematology and Oncology, Department of Internal Medicine, and
  • Kamal D. Puri, 4Calistoga Pharmaceuticals Inc, Seattle, WA; and
  • Brian J. Lannutti, 4Calistoga Pharmaceuticals Inc, Seattle, WA; and
  • Neill A. Giese, 4Calistoga Pharmaceuticals Inc, Seattle, WA; and
  • Xiaoli Zhang, 5Center for Biostatistics and
  • Lai Wei, 5Center for Biostatistics and
  • John C. Byrd, 2Division of Hematology and Oncology, Department of Internal Medicine, and 6Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus
  • Amy J. Johnson, 2Division of Hematology and Oncology, Department of Internal Medicine, and

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