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A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimens

Roberto Rodriguez, Ryotaro Nakamura, Joycelynne M. Palmer, Pablo Parker, Sepideh Shayani, Auyaporn Nademanee, David Snyder, Vinod Pullarkat, Neil Kogut, Joseph Rosenthal, Eileen Smith, Chatchada Karanes, Margaret O'Donnell, Amrita Y. Krishnan, David Senitzer and Stephen J. Forman
This article has an Erratum 115(21):4318

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  • Impact of preparative regimen on microangiopathy during m-TOR inhibitor based GVHD prophylaxis
    • Uwe Platzbecker, Hematologist
    • Other Contributors:
      • Gerhard Ehninger, Martin Bornh�user

    With interest we read the study by Rodriguez and colleagues demonstrating a considerable incidence of thrombotic microangiopathy (TMA) in patients receiving a combination of sirolimus with tacrolimus as GVHD prophylaxis after allogeneic HCT (1). In accordance with other reports these data are suggestive that pharmacological m-TOR inhibition increases the overall risk of TMA (2,3). Interestingly, the overall rate signif...

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    Conflict of Interest:
    None declared.