Blood Journal
Leading the way in experimental and clinical research in hematology

Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation

  1. Wen-Chien Chou1,2,
  2. Hsin-An Hou2,
  3. Chien-Yuan Chen2,
  4. Jih-Luh Tang2,
  5. Ming Yao2,
  6. Woei Tsay2,
  7. Bor-Shen Ko2,
  8. Shang-Ju Wu2,
  9. Shang-Yi Huang2,
  10. Szu-Chun Hsu1,
  11. Yao-Chang Chen1,
  12. Yen-Ning Huang1,
  13. Yi-Chang Chang1,
  14. Fen-Yu Lee3,
  15. Ming-Chi Liu3,
  16. Chia-Wen Liu3,
  17. Mei-Hsuan Tseng2,
  18. Chi-Fei Huang2, and
  19. Hwei-Fang Tien2
  1. Departments of 1Laboratory Medicine,
  2. 2Internal Medicine, Division of Hematology, and
  3. 3Pathology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan

Abstract

Mutations of nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase gene (IDH1) have been identified in patients with gliomas. Recent genome-wide screening also revealed IDH1 mutation as a recurrent event in acute myeloid leukemia (AML), but its clinical implications in AML are largely unknown. We analyzed 493 adult Chinese AML patients in Taiwan and found 27 patients (5.5%) harboring this mutation. IDH1 mutation was strongly associated with normal karyotype (8.4%, P = .002), isolated monosomy 8 (P = .043), NPM1 mutation (P < .001), and French-American-British M1 subtype (P < .001), but inversely associated with French-American-British M4 subtype (P = .030) and expression of HLA-DR, CD13, and CD14 (P = .002, .003, and .038, respectively). There was no impact of this mutation on patient survival. Sequential analysis of IDH1 mutation was performed in 130 patients during follow-ups. None of the 112 patients without IDH1 mutation at diagnosis acquired this mutation at relapse. In all 18 IDH1-mutated patients studied, the mutation disappeared in complete remission; the same mutation reappeared in all 11 samples obtained at relapse. We conclude that IDH1 is associated with distinct clinical and biologic characteristics and seems to be very stable during disease evolution.

  • Submitted November 6, 2009.
  • Accepted January 4, 2010.
View Full Text