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ATRA: Finding targeted APL therapy targets

Arati Khanna-Gupta and Nancy Berliner

Article Figures & Data

Figures

  • ATRA up-regulates UBE2D3 (E2) in APL cells, leading to ubiquitination of cyclin D1 (steps 1–4, numbered in red; see text). Monoubiquitinated cyclin D1 is then polyubiquitinated and degraded in the proteasome (step 5). In the absence of UBE2D3, cyclin D1 is not degraded and cells continue to cycle.