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CD10MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features

Kennosuke Karube, Ying Guo, Junji Suzumiya, Yasuo Sugita, Yuko Nomura, Kohei Yamamoto, Kei Shimizu, Shirou Yoshida, Hideki Komatani, Morishige Takeshita, Masahiro Kikuchi, Naoya Nakamura, Osamu Takasu, Fumiko Arakawa, Hiroyuki Tagawa, Masao Seto and Koichi Ohshima

Abstract

CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10MUM1+ with 119 typical CD10+MUM1 FLs. All CD10MUM1+ FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation, similar to typical FL. However, CD10MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1 typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10MUM1+ FL is different from typical FL with respect to biologic and clinical features.

  • Submitted September 8, 2006.
  • Accepted November 18, 2006.
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