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Blood, 15 October 2001, Vol. 98, No. 8, pp. 2577-2579
BRIEF REPORT
Effect of a large deletion of the basic domain of mi
transcription factor on differentiation of mast cells
Eiichi Morii,
Hideki Ogihara,
Keisuke Oboki,
Tatsuki R. Kataoka,
Kazutaka Maeyama,
David E. Fisher,
M. Lynn Lamoreux, and
Yukihiko Kitamura
From the Department of Pathology, Osaka University
Medical School, Suita, Japan; Department of Pharmacology, Ehime
University Medical School, Japan; Division of Pediatric
Hematology/Oncology, Dana Farber Cancer Institute and Children's
Hospital, Harvard Medical School, Boston, MA; and Department of
Veterinary Pathobiology, Texas A&M University, College Station, TX.
The mi transcription factor (MITF) is a
basic-helix-loop-helix-leucine zipper transcription factor that is
important for the development of mast cells. Cultured mast cells (CMCs)
of mi/mi genotype express abnormal MITF
(mi-MITF), but CMCs of tg/tg genotype do not
express any MITFs. It was previously reported that
mi/mi CMCs showed more severe abnormalities than
tg/tg CMCs, indicating that mi-MITF had
inhibitory function. Whereas mi-MITF contains a
single amino acid deletion in the basic domain, MITF encoded by
miew allele (ew-MITF) deletes 16 of
21 amino acids of the basic domain. Here the effect of a large deletion
of the basic domain was examined. In
miew/miew CMCs, the expression
pattern of genes whose transcription was affected by MITF was
comparable to that of tg/tg CMCs rather than to that of
mi/mi CMCs. This suggested that ew-MITF lacked
any functions. The part of the basic domain deleted in
ew-MITF appeared necessary for either transactivation or
inhibition of transactivation.
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