|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 3 (February 1), 2000:
pp. 802-806
Mucosa-associated lymphoid tissue lymphoma is a disseminated
disease in one third of 158 patients analyzed
Catherine Thieblemont,
Françoise Berger,
Charles Dumontet,
Isabelle Moullet,
Fadhela Bouafia,
Pascale Felman,
Gilles Salles, and
Bertrand Coiffier
From the Service d'hématologie and laboratoire
d'hématologie, Centre Hospitalier Lyon Sud, Pierre-Bénite,
France, and the Service d'Anatomie pathologique, Hôpital Edouard
Herriot, Lyon, France.
Mucosa-associated lymphoid tissue-derived lymphoma (MALT lymphoma)
is usually a very indolent lymphoma, described as localized at
diagnosis and remaining localized for a prolonged period; dissemination occurs only after a long course of evolution. In our database, out of
158 patients with MALT lymphoma, 54 patients presented with a
disseminated disease at diagnosis. Of these 54 patients, 17 patients
(30%) presented with multiple involved mucosal sites; 37 patients
(70%) presented with 1 involved mucosal site, but in 23 of these
patients (44%), dissemination of the disease was due to bone marrow
involvement; 12 patients (22%) had multiple lymph node involvement;
and 2 patients (4%) had nonmucosal site involvement. No significant
difference in clinical characteristics (sex, age, performance status,
B symptoms) and biological parameters (hemoglobin [Hb]
and lactate dehydrogenase levels) was observed between localized or
disseminated MALT-lymphoma patients. Only  2-microglobulin level was
significantly more elevated in disseminated disease patients than in
localized disease patients. Complete response after the first treatment
was achieved in 74% of the patients, and there was no difference
between the 2 groups. With a median follow-up of 4 years, the estimated
5- and 10-year overall survival rates were similar in the 2 groups,
86% and 80%, respectively. The median freedom-from-progression
survival was 5.6 years for all patients, surprisingly without any
difference between localized and disseminated MALT-lymphoma patients.
In conclusion, MALT lymphoma is an indolent disease but presents as a
disseminated disease in one-third of the cases at diagnosis. The
dissemination does not change the outcome of the patients.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Colombat, H. Mal, C. Copie-Bergman, J. Diebold, D. Damotte, P. Callard, M. Fournier, J.-P. Farcet, M. Stern, and M.-H. Delfau-Larue
Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor
Blood,
September 1, 2008;
112(5):
2004 - 2012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Papaxoinis, G. Fountzilas, D. Rontogianni, M. A. Dimopoulos, N. Pavlidis, C. Tsatalas, D. Pectasides, N. Xiros, and T. Economopoulos
Low-grade mucosa-associated lymphoid tissue lymphoma: a retrospective analysis of 97 patients by the Hellenic Cooperative Oncology Group (HeCOG)
Ann. Onc.,
April 1, 2008;
19(4):
780 - 786.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. de Boer, R. F. Hiddink, M. Raderer, N. Antonini, B. M. P. Aleman, H. Boot, and D. de Jong
Dissemination patterns in non-gastric MALT lymphoma
Haematologica,
February 1, 2008;
93(2):
201 - 206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Tanimoto, A. Kaneko, S. Suzuki, N. Sekiguchi, T. Watanabe, Y. Kobayashi, Y. Kagami, A. M. Maeshima, Y. Matsuno, and K. Tobinai
Primary Ocular Adnexal MALT Lymphoma: A Long-term Follow-up Study of 114 Patients
Jpn. J. Clin. Oncol.,
June 11, 2007;
(2007)
hym031v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tsai, S Li, A. Ng, B Silver, M. Stevenson, and P. Mauch
Role of radiation therapy in the treatment of stage I/II mucosa-associated lymphoid tissue lymphoma
Ann. Onc.,
April 1, 2007;
18(4):
672 - 678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M Bacon, M.-Q. Du, and A. Dogan
Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists
J. Clin. Pathol.,
April 1, 2007;
60(4):
361 - 372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Arcaini, S Burcheri, A Rossi, M Paulli, R Bruno, F Passamonti, E Brusamolino, A Molteni, A Pulsoni, M. Cox, et al.
Prevalence of HCV infection in nongastric marginal zone B-cell lymphoma of MALT
Ann. Onc.,
February 1, 2007;
18(2):
346 - 350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Streubel, D. Huber, S. Wohrer, A. Chott, and M. Raderer
Reverse Transcription-PCR for t(11;18)(q21;q21) Staging and Monitoring in Mucosa-Associated Lymphoid Tissue Lymphoma.
Clin. Cancer Res.,
October 15, 2006;
12(20):
6023 - 6028.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Decaudin, P. de Cremoux, A. Vincent-Salomon, R. Dendale, and L. L.-L. Rouic
Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options
Blood,
September 1, 2006;
108(5):
1451 - 1460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Raderer, S. Wohrer, B. Streubel, M. Troch, K. Turetschek, U. Jager, C. Skrabs, A. Gaiger, J. Drach, A. Puespoek, et al.
Assessment of Disease Dissemination in Gastric Compared With Extragastric Mucosa-Associated Lymphoid Tissue Lymphoma Using Extensive Staging: A Single-Center Experience
J. Clin. Oncol.,
July 1, 2006;
24(19):
3136 - 3141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M-Q Du and J C Atherton
Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management.
Gut,
June 1, 2006;
55(6):
886 - 893.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Arcaini, S. Burcheri, A. Rossi, F. Passamonti, M. Paulli, E. Boveri, E. Brusamolino, E. Orlandi, A. Molteni, A. Pulsoni, et al.
Nongastric Marginal-Zone B-Cell MALT Lymphoma: Prognostic Value of Disease Dissemination.
Oncologist,
March 1, 2006;
11(3):
285 - 291.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Tanimoto, A. Kaneko, S. Suzuki, N. Sekiguchi, D. Maruyama, S. W. Kim, T. Watanabe, Y. Kobayashi, Y. Kagami, A. Maeshima, et al.
Long-term follow-up results of no initial therapy for ocular adnexal MALT lymphoma
Ann. Onc.,
January 1, 2006;
17(1):
135 - 140.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Sankaranarayanan, T. M. Zeidalski, and R. K. Chitkara
A 55-Year-Old Smoker With a Persistent Right Lower Lobe Infiltrate
Chest,
June 1, 2005;
127(6):
2266 - 2270.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Thieblemont
Clinical Presentation and Management of Marginal Zone Lymphomas
Hematology,
January 1, 2005;
2005(1):
307 - 313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bendandi, S. A. Pileri, and P. L. Zinzani
Challenging paradigms in lymphoma treatment
Ann. Onc.,
May 1, 2004;
15(5):
703 - 711.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Tsang, M. K. Gospodarowicz, M. Pintilie, W. Wells, D. C. Hodgson, A. Sun, M. Crump, and B. J. Patterson
Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical Outcome
J. Clin. Oncol.,
November 15, 2003;
21(22):
4157 - 4164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Conconi, G. Martinelli, C. Thieblemont, A. J. M. Ferreri, L. Devizzi, F. Peccatori, M. Ponzoni, E. Pedrinis, S. Dell'Oro, G. Pruneri, et al.
Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type
Blood,
October 15, 2003;
102(8):
2741 - 2745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ye, H. Liu, A. Attygalle, A. C. Wotherspoon, A. G. Nicholson, F. Charlotte, V. Leblond, P. Speight, J. Goodlad, A. Lavergne-Slove, et al.
Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma
Blood,
August 1, 2003;
102(3):
1012 - 1018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Seymour, B. Pro, L. M. Fuller, J. T. Manning, F. B. Hagemeister, J. Romaguera, M. A. Rodriguez, C. S. Ha, T. L. Smith, A. Ayala, et al.
Long-Term Follow-Up of a Prospective Study of Combined Modality Therapy for Stage I-II Indolent Non-Hodgkin's Lymphoma
J. Clin. Oncol.,
June 1, 2003;
21(11):
2115 - 2122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Zucca, A. Conconi, E. Pedrinis, S. Cortelazzo, T. Motta, M. K. Gospodarowicz, B. J. Patterson, A. J. M. Ferreri, M. Ponzoni, L. Devizzi, et al.
Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
Blood,
April 1, 2003;
101(7):
2489 - 2495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Streubel, A. Lamprecht, J. Dierlamm, L. Cerroni, M. Stolte, G. Ott, M. Raderer, and A. Chott
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
Blood,
March 15, 2003;
101(6):
2335 - 2339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cadranel, M. Wislez, and M. Antoine
Primary pulmonary lymphoma
Eur. Respir. J.,
September 1, 2002;
20(3):
750 - 762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Cavalli, P. G. Isaacson, R. D. Gascoyne, and E. Zucca
MALT Lymphomas
Hematology,
January 1, 2001;
2001(1):
241 - 258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
