|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 93 No. 8 (April 15), 1999:
pp. 2463-2470
Differential Chemokine Expression in Tissues Involved by Hodgkin's
Disease: Direct Correlation of Eotaxin Expression and Tissue
Eosinophilia
Julie Teruya-Feldstein,
Elaine S. Jaffe,
Parris R. Burd,
Douglas
W. Kingma,
Joyce E. Setsuda, and
Giovanna Tosato
From the Laboratory of Pathology, Hematopathology Section, National
Cancer Institute, National Institutes of Health, Bethesda; and the
Center for Biologics Evaluation and Research, Food and Drug
Administration, Bethesda, MD.
Hodgkin's disease (HD) is a lymphoid malignancy characterized by
infrequent malignant cells surrounded by abundant inflammatory cells.
In this study, we examined the potential contribution of chemokines to
inflammatory cell recruitment in different subtypes of HD. Chemokines
are small proteins that are active as chemoattractants and regulators
of cell activation. We found that HD tissues generally express higher
levels of interferon- -inducible protein-10 (IP-10), Mig, RANTES,
macrophage inflammatory protein-1 (MIP-1), and eotaxin, but not
macrophage-derived chemotactic factor (MDC), than tissues
from lymphoid hyperplasia (LH). Within HD subtypes, expression of IP-10
and Mig was highest in the mixed cellularity (MC) subtype, whereas
expression of eotaxin and MDC was highest in the nodular sclerosis (NS)
subtype. A significant direct correlation was detected between evidence
of Epstein-Barr virus (EBV) infection in the neoplastic cells and
levels of expression of IP-10, RANTES, and MIP-1. Levels of eotaxin
expression correlated directly with the extent of tissue eosinophilia.
By immunohistochemistry, IP-10, Mig, and eotaxin proteins localized in
the malignant Reed-Sternberg (RS) cells and their variants, and to some
surrounding inflammatory cells. Eotaxin was also detected in
fibroblasts and smooth muscle cells of vessels. These results provide
evidence of high level chemokine expression in HD tissues and suggest
that chemokines may play an important role in the recruitment of
inflammatory cell infiltrates into tissues involved by HD.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Y. Ma, L. Visser, H. Roelofsen, M. de Vries, A. Diepstra, G. van Imhoff, T. van der Wal, M. Luinge, G. Alvarez-Llamas, H. Vos, et al.
Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes
Blood,
February 15, 2008;
111(4):
2339 - 2346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Re, R. Kuppers, and V. Diehl
Molecular Pathogenesis of Hodgkin's Lymphoma
J. Clin. Oncol.,
September 10, 2005;
23(26):
6379 - 6386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Weihrauch, O. Manzke, M. Beyer, H. Haverkamp, V. Diehl, H. Bohlen, J. Wolf, and J. L. Schultze
Elevated Serum Levels of CC Thymus and Activation-Related Chemokine (TARC) in Primary Hodgkin's Disease: Potential for a Prognostic Factor
Cancer Res.,
July 1, 2005;
65(13):
5516 - 5519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tefferi
Blood Eosinophilia: A New Paradigm in Disease Classification, Diagnosis, and Treatment
Mayo Clin. Proc.,
January 1, 2005;
80(1):
75 - 83.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. B. Kodali, W. J.H. Kim, I. I. Galaria, C. Miller, A. D. Schecter, S. A. Lira, and M. B. Taubman
CCL11 (Eotaxin) Induces CCR3-Dependent Smooth Muscle Cell Migration
Arterioscler. Thromb. Vasc. Biol.,
July 1, 2004;
24(7):
1211 - 1216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Cahir-McFarland, K. Carter, A. Rosenwald, J. M. Giltnane, S. E. Henrickson, L. M. Staudt, and E. Kieff
Role of NF-{kappa}B in Cell Survival and Transcription of Latent Membrane Protein 1-Expressing or Epstein-Barr Virus Latency III-Infected Cells
J. Virol.,
April 15, 2004;
78(8):
4108 - 4119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hanamoto, T. Nakayama, H. Miyazato, S. Takegawa, K. Hieshima, Y. Tatsumi, A. Kanamaru, and O. Yoshie
Expression of CCL28 by Reed-Sternberg Cells Defines a Major Subtype of Classical Hodgkin's Disease with Frequent Infiltration of Eosinophils and/or Plasma Cells
Am. J. Pathol.,
March 1, 2004;
164(3):
997 - 1006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Atasoy, S. L. Curry, I. Lopez de Silanes, A.-B. Shyu, V. Casolaro, M. Gorospe, and C. Stellato
Regulation of Eotaxin Gene Expression by TNF-{alpha} and IL-4 Through mRNA Stabilization: Involvement of the RNA-Binding Protein HuR
J. Immunol.,
October 15, 2003;
171(8):
4369 - 4378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. F. Skinnider and T. W. Mak
The role of cytokines in classical Hodgkin lymphoma
Blood,
May 29, 2002;
99(12):
4283 - 4297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Cheng, N. W. Lukacs, and S. L. Kunkel
Eotaxin/CCL11 Suppresses IL-8/CXCL8 Secretion from Human Dermal Microvascular Endothelial Cells
J. Immunol.,
March 15, 2002;
168(6):
2887 - 2894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. J. Jabs, H. J. Wagner, S. Maurmann, H. Hennig, and B. Kreft
Inhibition of macrophage inflammatory protein-1alpha production by Epstein-Barr virus
Blood,
March 1, 2002;
99(5):
1512 - 1516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. E. Hopken, H.-D. Foss, D. Meyer, M. Hinz, K. Leder, H. Stein, and M. Lipp
Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs
Blood,
February 15, 2002;
99(4):
1109 - 1116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Aldinucci, D. Poletto, A. Gloghini, P. Nanni, M. Degan, T. Perin, P. Ceolin, F. M. Rossi, V. Gattei, A. Carbone, et al.
Expression of Functional Interleukin-3 Receptors on Hodgkin and Reed-Sternberg Cells
Am. J. Pathol.,
February 1, 2002;
160(2):
585 - 596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. F. Skinnider, A. J. Elia, R. D. Gascoyne, B. Patterson, L. Trumper, U. Kapp, and T. W. Mak
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
Blood,
January 15, 2002;
99(2):
618 - 626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Fiumara, V. Snell, Y. Li, A. Mukhopadhyay, M. Younes, A. M. Gillenwater, F. Cabanillas, B. B. Aggarwal, and A. Younes
Functional expression of receptor activator of nuclear factor kappa B in Hodgkin disease cell lines
Blood,
November 1, 2001;
98(9):
2784 - 2790.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Lopatin, X. Yao, R. K. Williams, J. J. H. Bleesing, J. K. Dale, D. Wong, J. Teruya-Feldstein, S. Fritz, M. R. Morrow, I. Fuss, et al.
Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression
Blood,
May 15, 2001;
97(10):
3161 - 3170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Buri, M. Korner, P. Scharli, D. Cefai, M. Uguccioni, C. Mueller, J. A. Laissue, and L. Mazzucchelli
CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease
Blood,
March 15, 2001;
97(6):
1543 - 1548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. von Wasielewski, S. Seth, J. Franklin, R. Fischer, K. Hubner, M. L. Hansmann, V. Diehl, and A. Georgii
Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors
Blood,
February 15, 2000;
95(4):
1207 - 1213.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
