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Blood, Vol. 93 No. 8 (April 15), 1999:
pp. 2449-2453
RAPID COMMUNICATION
Association of the Platelet Glycoprotein Ia C807T
Gene Polymorphism With Nonfatal Myocardial Infarction in Younger
Patients
S. Santoso,
T.J. Kunicki,
H. Kroll,
W. Haberbosch, and
A. Gardemann
From the Institute for Clinical Immunology and Transfusion Medicine,
Justus Liebig University Giessen, Giessen, Germany; The Scripps
Research Institute, La Jolla, CA; The Max Planck Institute for
Experiment and Clinical Research, Kerckhoff Hospital, Bad Nauheim,
Germany; and the Institute for Clinical Chemistry and
Pathobiochemistry, Justus Liebig University Giessen, Giessen, Germany.
Recently, we have shown that two alleles of the glycoprotein (GP) Ia
gene, designated C807 and T807, are associated
with low or high platelet GPIa-IIa density and consequently with slower or faster rate of platelet adhesion to type I collagen, respectively. This polymorphism could therefore present a genetic predisposition for
the development of thrombotic disease and hemostasis. We investigated the relationship of the GPIa C807T dimorphism to the risk
of coronary artery disease (CAD) and myocardial infarction (MI). An
allele-specific polymerase chain reaction (PCR) was developed for
genotyping of C807T polymorphism. DNA samples from 2237 male patients who underwent coronary angiography on account of coronary
heart disease as verified illness or presumptive diagnosis were
genotyped. The odds ratio was calculated as an estimate of the relative
risk by multiple logistic regression. We found a strong association
between the T allele and nonfatal MI among individuals younger than the
mean age of 62 years (n = 1,057; odds ratio, 1.57; P = .004). The odds ratio of MI increased for T807 carriers
with decreasing age. The highest odds ratio was detected within the
youngest 10% of the study sample (<49 years; n = 223; odds ratio,
2.61; P = .009). In contrast, no evidence of an association
between C807T dimorphism with CAD was found. Our findings
suggest that inherited platelet GP variations might have an important
impact on acute thrombotic disease.
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