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BCL-2 but not its Epstein-Barr virus-encoded homologue, BHRF1, is commonly
expressed in posttransplantation lymphoproliferative disorders [see
comments]
PG Murray, LJ Swinnen, CM Constandinou, JM Pyle, TJ Carr, JM Hardwick and RF Ambinder
Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.
Posttransplantation lymphoproliferative disease (PTLD) is virtually always
associated with Epstein-Barr virus (EBV) infection. BCL-2 and other
proteins that confer resistance to apoptosis have been implicated in the
pathogenesis of a variety of malignancies including lymphomas. One EBV
protein, BHRF1, is a homologue of BCL-2, whereas another, the latency
membrane protein 1 (LMP-1), upregulates BCL-2 expression in vitro. In the
present study, we used immunohistochemistry to study the expression of
these viral and cellular proteins as well as a variety of other EBV-encoded
proteins in PTLD. BHRF1 was not detected in any PTLD specimen, whereas
BCL-2 was shown in 12 of 17 lesions examined. With one exception, all
LMP1-positive cases also expressed BCL-2 and the absence of LMP1 was always
associated with a lack of BCL-2 expression. The results do not support a
role for the EBV homologue of BCL-2 in PTLD, but they do support a role for
viral induction of BCL-2 expression.
Volume 87,
Issue 2,
pp. 706-711,
01/15/1996
Copyright © 1996 by The American Society of Hematology
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