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Differential expression of CD24-related epitopes in mycosis
fungoides/Sezary syndrome: a potential marker for circulating Sezary cells
SJ Pirruccello and MS Lang
Department of Pathology and Microbiology, University of Nebraska Medical
Center, Omaha 68105-1065.
In the hematopoietic system, the B-cell associated antigen CD24 is
expressed at high density on B cells, B-cell precursors, and B-cell
malignancies as well as at low density on peripheral blood
polymorphonuclear leukocytes. The 42-Kd sialoglycoprotein has not been
previously demonstrated to be expressed on T cells, thymocytes, or T- cell
malignancies. We identified three patients with mycosis fungoides/Sezary
syndrome that showed low density expression of the CD24-related epitope
recognized by antibody BA-1 on circulating T cells. All three patients had
Sezary cells by morphologic assessment and clonal T-cell populations in the
peripheral blood by gene rearrangement studies. In two of these patients,
indirect immunofluorescence with a panel of six anti-CD24 monoclonal
antibodies demonstrated reactivity for two of six antibodies in one case
and only one of six antibodies in the other. The biologic significance of
CD24- related epitope expression on circulating T cells in mycosis
fungoides/Sezary syndrome is unclear. However, these findings suggest that
differential, low density expression of CD24-related epitopes (BA- 1+,
OKB2-) may be a useful phenotypic marker for identifying circulating Sezary
cells.
Volume 76,
Issue 11,
pp. 2343-2347,
12/01/1990
Copyright © 1990 by The American Society of Hematology
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