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Four new recurring translocations in non-Hodgkin lymphoma
EG Levine, DC Arthur, J Machnicki, G Frizzera, D Hurd, B Peterson, KJ Gajl- Peczalska and CD Bloomfield
Department of Medicine, University of Minnesota, Minneapolis.
The identification of recurring chromosomal translocations has provided
clues to the gene regions important in lymphoma development. Among 157
patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four
new recurring translocations have been identified--t(8;9) (q24;p13),
t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation
giving rise to der(22)t(17;22) (q11;p11). Each translocation appeared
twice. The t(11;18) was the only karyotypic abnormality in the two patients
with it, and the t(14;15) was the sole karyotypic abnormality in one
patient. All translocations were found in B-cell malignancies and were
associated with both nodal and extranodal disease. Among the regions
affected, only the immunoglobulin heavy- chain gene MYC, and BCL2, have
thus far been associated with lymphoma. The breakpoint sites identified by
these translocations warrant further investigation at the molecular level.
Volume 74,
Issue 5,
pp. 1796-1800,
10/01/1989
Copyright © 1989 by The American Society of Hematology
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