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M Nishimura, M Inoue, T Nakano, T Nishikawa, M Miyamoto, T Kobayashi and Y Kitamura
Department of Anatomy, Hamamatsu University School of Medicine, Shizuoka,
Japan.
Although Chediak-Higashi syndrome (CHS) has been found in various mammalian
species, it has not been described in rats. Since giant granules
characterizing CHS are easily recognizable in mast cells of beige (CHS)
mice, we screened mast-cell granules in the auricle of some mutant rats, of
which coat color was diluted by mutation. Giant granules of mast cells were
found in a mutant trait that occurred in the inbred colony of the DA strain
rat maintained in Hamamatsu University School of Medicine. Giant granules
were also observed in neutrophils and pigment cells of the eye. In this
mutant, either spontaneous migration or chemotaxis of neutrophils was
impaired, and the bleeding time was prolonged. Blood serotonin level of the
mutant was about one tenth that of the normal congenic rat, and injection
of serotonin normalized the bleeding time of the mutant. Moreover, the
natural killer activity of the mutant was significantly impaired. These
results indicated that this mutation was comparable to CHS of humans and
mice, and we designated it as "beige." Since rats are more favorable than
mice for some types of experiments, the beige rat is potentially useful as
an animal model of CHS.
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| Copyright © 1989 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
