|
|
 Previous Article | Table of Contents | Next Article 
Site-selective cAMP analogs at micromolar concentrations induce growth
arrest and differentiation of acute promyelocytic, chronic myelocytic, and
acute lymphocytic human leukemia cell lines
G Tortora, P Tagliaferri, T Clair, O Colamonici, LM Neckers, RK Robins and YS Cho- Chung
Laboratory of Tumor Immunology and Biology, National Cancer Institute,
Bethesda, MD 20892.
Cyclic AMP (cAMP)-dependent protein kinase may play a role in the
functional and morphological differentiation of leukemic cells. In this
study, we showed that the cAMP analogs, potent activators of protein kinase
recently shown to be selective for either site 1 or site 2 cAMP binding
sites of protein kinase, demonstrate potent growth inhibition of acute
promyelocytic, chronic myelocytic, and acute lymphocytic leukemic cell
lines with no sign of toxicity. The growth inhibition accompanied monocytic
differentiation in HL-60 cells and a loss of nuclear terminal
deoxynucleotidyl transferase activity in Molt-4 leukemic cells. The growth
inhibition also paralleled a decrease in c- myc protein and RI cAMP
receptor protein. Thus, cAMP analogs selective for either site 1 or site 2
of the protein kinase appear to restore a coupling of proliferation and
maturation in leukemic cells.
Volume 71,
Issue 1,
pp. 230-233,
01/01/1988
Copyright © 1988 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Leszczyniecka, D.-c. Kang, D. Sarkar, Z.-z. Su, M. Holmes, K. Valerie, and P. B. Fisher
Identification and cloning of human polynucleotide phosphorylase, hPNPaseold-35, in the context of terminal differentiation and cellular senescence
PNAS,
December 24, 2002;
99(26):
16636 - 16641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Zhu, J.-W. Zhang, H.-Q. Zhu, Y.-L. Shen, M. Flexor, P.-M. Jia, Y. Yu, X. Cai, S. Waxman, M. Lanotte, et al.
Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk
Blood,
February 1, 2002;
99(3):
1014 - 1022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Propper, M. P. Saunders, A. J. Salisbury, L. Long, K. J. O'Byrne, J. P. Braybrooke, M. Dowsett, M. Taylor, D. C. Talbot, T. S. Ganesan, et al.
Phase I Study of the Novel Cyclic AMP (cAMP) Analogue 8-Chloro-cAMP in Patients with Cancer: Toxicity, Hormonal, and Immunological Effects
Clin. Cancer Res.,
July 1, 1999;
5(7):
1682 - 1689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
