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Control of hemopoiesis by a bone marrow stromal cell clone:
lipopolysaccharide- and interleukin-1-inducible production of colony-
stimulating factors
D Rennick, G Yang, L Gemmell and F Lee
A stromal cell line, GY30, was cloned from mouse bone marrow adherent cell
layers. In culture, GY30 cells sustain the production of
granulocyte-macrophage progenitor cells (GM-CFU) but fail to support the
survival of pluripotential stem cells (CFU-S). GY30 cells secrete two
growth factor activities distinct from interleukin-3 (IL-3), IL-2, and
macrophage colony-stimulating factor (M-CSF) but functionally similar to
GM-CSF and G-CSF. The production of both CSFs is increased 70- to 200-fold
by treating GY30 cells with lipopolysaccharide or IL-1. RNA blot analysis
reveals the presence of GM-CSF and G-CSF transcripts and demonstrates that
IL-1 regulates the production of both factors at the mRNA level. Further,
these studies show that the GM-CSF secreted by GY30 cells is structurally
similar to the GM-CSF produced by activated T cells.
Volume 69,
Issue 2,
pp. 682-691,
02/01/1987
Copyright © 1987 by The American Society of Hematology
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