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A new translocation, t(10;14)(q24;q11), in T cell neoplasia
ID Dube, SC Raimondi, D Pi and DK Kalousek
Four cases of T cell neoplasia are reported: three presenting as T cell
acute lymphoblastic leukemia and one presenting in the leukemic phase of a
T cell lymphoma. In all cases, the cells of the leukemic clone were
characterized by an identical cytogenetic abnormality. This abnormality was
a unique reciprocal translocation involving chromosomes 10 and 14. The
breakpoint in chromosome 14 was in band q11, coincident with the assigned
locus of the alpha-chain gene of the T cell antigen receptor. The
breakpoint in chromosome 10 was in band q24, a region reported to include
the locus of the terminal deoxynucleotidyltransferase (TdT) gene. Our
observations suggest that translocation t(10;14)(q24;q11) is specific for T
cell neoplasia and that a gene in chromosomal band 10q24, possibly the TdT
gene, plays an important role in T cell neoplasia when its expression or
coding sequence is altered by aberrant recombination involving a T cell
antigen receptor gene.
Volume 67,
Issue 4,
pp. 1181-1184,
04/01/1986
Copyright © 1986 by The American Society of Hematology
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